Patricia A. Relue

Cellular Engineering Laboratory
Department of Bioengineering
The University of Toledo

Patricia A. Relue

Education:

May 1990 - Feb. 1994	The University of Michigan, Ann Arbor, MI Ph.D. in Chemical Engineering Thesis Advisor: Jennifer J. Linderman
Aug. 1988 - May 1990	The University of Michigan, Ann Arbor, MI M.S. in Engineering
Sept. 1984 - Aug. 1988	The University of Toledo, Toledo, OH B.S. in Chemical Engineering Magna Cum Laude, with Honors

Academic Appointment Record:

Mar. 2002 –present	The University of Toledo, Toledo, OH Graduate Program Director, Department of Bioengineering
May 2001 – Dec. 2001	New Jersey Institute of Technology, Newark, NJ Visiting Faculty (Sabbatical Leave, Department of Electrical and Computer Engineering)
Apr. 1999 – present	The University of Toledo, Toledo, OH Associate Professor, Department of Bioengineering and Department of Chemical & Environmental Engineering
Sept. 2000 - May 2001 May 1999 – Nov. 1999	The University of Toledo, Toledo, OH Undergraduate Program Director, Department of Bioengineering
July 1996 – Apr. 1999	The University of Toledo, Toledo, OH Assistant Professor, Department of Bioengineering and Department of Chemical & Environmental Engineering
Mar. 1995 – present	Medical College of Ohio, Toledo, OH Adjunct Assistant Professor, Department of Pathology
Nov. 1993 – July 1996	The University of Toledo, Toledo, OH Assistant Professor, Department of Chemical Engineering

Refereed Journal Publications:

K. Rao; S. Chelikani; P. Relue; and. S. Varanasi, “A Novel technique for Optimizing the Simultaneous-Isomerization-and-Fermentation (SIF) Approach of Converting Xylose to Ethanol,” Applied Biochemistry and Biotechnology, 146(1-3):101-117, 2008.

Y.Yuan and P. Relue, “Enzymatic degradation of human skin dermis revealed by fluorescence and reflectance spectroscopy,” Optics Express, 16(13):9857-9868, June 20, 2008.

Y. Yuan, Y. Li, B.D. Cameron, and P.A. Relue, “Fluorescence anisotropy of cellular NADH as a tool to study different metabolic properties of human melanocytes and melanoma cells,” IEEE Journal of Selected Topics in Quantum Electronics, 13(6):1671-1679, Nov/Dec 2007.

S.V. Patwardhan, A.P. Dhawan, and P.A. Relue, “Monte Carlo Simulation of Light-Tissue Interaction: Three-Dimensional Voxel Based Simulation for Trans-Illumination-Based Imaging of Skin Lesions,” IEEE Transactions on Biomedical Engineering, 52(7):1227-1236, July 2005.

S.V. Patwardhan, A.P. Dhawan, and P.A. Relue, “Classification of Melanoma Using Tree-Structured Wavelet Transforms,” Computer Methods and Programs in Biomedicine, Nov. 2003, 72(3):223-239.

B. Cheng, R.L. Fournier, P.A. Relue, and J. Schisler, “An experimental and theoretical study of the inhibition of Escherichia coli lac operon gene expression by antigene oligonucleotides,” Biotechnology and Bioengineering, 74(3):220-229, 2001.

B. Cheng, R.L. Fournier, and P.A. Relue, “The Inhibition of Escherichia coli lac Operon Gene Expression by Antigene Oligonucleotides – Mathematical Modeling,” Biotechnology and Bioengineering, 70(4):467-472, 2000.

J. Yuan, P.A. Mahama-Relue, R.L. Fournier, and J. Hampton, “Mathematical Model Predictions of Tissue Oxygenation and Singlet Oxygen Generation During Photodynamic Therapy”, Radiation Research, 148:386-394, 1997.

G. Chen, R.L. Fournier, S. Varanasi, and P.A. Mahama-Relue, “Helicobacter pylori Survival in Gastric Mucosa by Generation of a pH Gradient”, Biophysical Journal, 73(2):1081-1088, 1997.

P.A. Mahama and J.J. Linderman, “Monte Carlo Simulations of Membrane Signal Transduction Events: Effect of Receptor Blockers on G-Protein Activation,” Annals of Biomedical Engineering, 23:299-307, 1995.

P.A. Mahama and J.J. Linderman “A Monte Carlo Study of the Dynamics of G-Protein Activation,” Biophysical Journal, 67:1345-1357, 1994.

P.A. Mahama and J.J. Linderman “Calcium Signaling in Individual BC3H1 Cells: Speed of Calcium Mobilization and Heterogeneity”, Biotechnology Progress, 10:45-54, 1994.

Patents:

S. Varanasi, K. Rao, and P. Relue, “A Novel technique that enables efficient fermentation of xylose and hexose sugars from biomass hydrolysates using native non-GMO yeasts,” US Utility Patent filed, January 2009.

“Method to Monitor Metabolic Changes in Living Cells Using Endogenous Polarization-Sensitive Fluorescence,” Y. Yuan, P. Relue, B.D. Cameron, U.S. Provisional Patent Application, Serial No. 60/843,183; Filed September 8, 2006. Utility Patent Application: Filed September 1, 2007.

Conference Papers:

S.V. Patwardhan, A.P. Dhawan, and P.A. Relue, “Multi-Spectral Light Tissue Interaction Modeling for Skin Lesion Imaging,” 25^th Proceedings of the Annual International Conference – IEEE EMBS, 2003, vol. 2:1019-1022.

S.V. Patwardhan, A.P. Dhawan, and P.A. Relue, “Wavelength Selection for Multi-Spectral Imaging of Skin Lesions,” Proc. IEEE 29^th Annual Northeast Bioengineering Conference, 2003, p. 327-328.

S.V. Patwardhan, A.P. Dhawan, and P.A. Relue, “Tree structured wavelet transform signature for classification of melanoma,” SPIE Proceeding on Medical Imaging, (4684-123) S15, February 2002.

A.J. Nimunkar, A.P. Dhawan, P.A. Relue, and S.V. Patwardhan, “Wavelet and statistical analysis for melanoma classification,” SPIE Proceeding on Medical Imaging, (4684-156) S16, February 2002.

S.T. Sharfstein and P.A. Relue, “Biotechnology and Bioprocessing Laboratory for Chemical Engineering and Bioengineering, Proceedings of the 2001 ASEE Annual Conference & Exposition, June 2001.

J.A. Hampton, P.A. Mahama, R.L. Fournier, and J.P. Henning, “Photodynamic Therapy: Computer Modeling of Diffusion and Reaction Phenomena”, SPIE Proceedings, vol. 2675, January 1996.

Conference Presentations, Abstracts, and Posters:
First author is presenter; 8 most recent of 27

K. Rao, S. Varanasi, P. Relue, “A Novel Approach for Conversion of Xylose to Ethanol Using Native Strains of Yeast,” 30th Symposium on Biotechnology for Fuels & Chemicals, New Orleans, LA, May 2008.

K. Rao, S. Varanasi, P. Relue, C. Schall, “A Novel Approach for Conversion of Xylose to Ethanol Using Native Yeast Strains,” AIChE 2007 Annual Meeting, Salt Lake City, UT, Nov 5-9, 2007.

K. Rao, S. Chelikani, P. Relue, and. S. Varanasi, “A Novel technique for Optimizing the Simultaneous-Isomerization-and-Fermentation (SIF) Approach of Converting Xylose to Ethanol,” Symposium on Biotechnology for Fuels & Chemicals. Denver, CO, May 2007.

K. Rao, S. Chelikani, R. Fournier, P. Relue and S. Varanasi, “Novel Approach for Conversion of Xylose to Ethanol,” AIChE 2006 Annual Meeting, San Francisco, CA, Nov 12-17, 2006.

Y. Yuan, P.A. Relue, and B.D. Cameron, “Fluorescence Anisotropy Investigation of Metabolic Properties of Human Melanocytes and Melanoma Cells,” BMES Annual Meeting, Chicago, IL Oct 11-14, 2006.

P. Relue and T. Phares, “Bioprocessing Laboratory at the University of Toledo,” PEBEL Conference on Laboratory Partnership, June 4-6, 2004, National Conference Center, Lansdowne, VA.

Y. Yuan, Y. Li, R. Criss, P. A. Relue, B.D. Cameron, “Polarized fluorescence spectroscopy of skin for potential tissue diagnostics”, Great Lakes Photonics Symposium, June 7-11, 2004, Case Western Reserve University.

S.V. Patwardhan, A.P. Dhawan, and P.A. Relue, “Wavelength Selection for Multi-Spectral Imaging of Skin Lesions,” Proc. IEEE 29^th Annual Northeast Bioengineering Conference, 2003, p. 327-328.

Recent Courses Taught:

BIOE 1000	Orientation & Intro to Bioengineering	Fall 2009
BIOE 2100	Thermodynamics	Spring 2005
BIOE 2200	Biomaterials	Fall 2005
BIOE 3500	Bioprocessing Laboratory	Fall 2009
BIOE 4/5740	Tissue Engineering	Spring 2009
BIOE 5/7310	Research Methods	Fall 2007
BIOE 5/7990	Biophotonics	Spring 2003

Honors and Awards:

2007	Outstanding Teacher Award, College of Engineering, The University of Toledo
2005-06	Outstanding Professor in Bioengineering Award, BMES, The University of Toledo
1998	Dean’s Merit Award, College of Engineering, The University of Toledo
1997	Sigma Xi, The University of Toledo
1997	Outstanding Teacher Award, The University of Toledo
1996-97	Outstanding Teaching in Bioengineering Award Biomedical Engineering Society, The University of Toledo